Project:

FFCastanea

Start date: 15/07/2018
End date: 15/01/2022
Project reference number: PTDC/ASP-AGR/29277/2017

Castanea sativa shells as a new source of active ingredients for Functional Food and Cosmetic applications: a sustainable approach

Responsible Researcher: Francisca Rodrigues

Proposing Institution: REQUIMTE – Rede de Química e Tecnologia

Funding: The project FFCASTANEA (PTDC/ASP-AGR/29277/2017) was funded by the Fundação para a Ciência e a Tecnologia (FCT), Ministério da Ciência, Tecnologia e Ensino Superior, through national funds.

Articles in Peer Reviewed Journals

1. Ana Sofia Ferreira, Ana Margarida Silva, Emily P. Laveriano-Santos, Julián Lozano-Castellón, Rosa M. Lamuela-Raventós, Jaroslava Švarc-Gajíc, Cristina Delerue-Matos, Berta N. Estevinho, Paulo C. Costa, Francisca Rodrigues, Development and characterization of spray-drying microparticles loaded with chestnut shells extract: New insights for oral mucositis therapy, Powder Technology, 2024, 446, 120182
https://doi.org/10.1016/j.powtec.2024.120182

2. Diana Pinto, Manuela M. Moreira, Anna Vallverdú-Queralt, Cristina Delerue-Matos, Francisca Rodrigues, Insights into the digestion of chestnut (Castanea sativa) shells bioactive extracts – ultrasound vs. microwave-assisted extraction, International Journal of Food Science and Technology, 2024, 59, 5128–5142
https://doi.org/10.1111/ijfs.17253

3. Diana Pinto, Julián Lozano-Castellón, Ana Margarida Silva, María de la Luz Cádiz-Gurrea, Antonio Segura-Carretero, Rosa Lamuela-Raventós, Anna Vallverdú-Queralt, Cristina Delerue-Matos, Francisca Rodrigues, Novel insights into enzymes inhibitory responses and metabolomic profile of supercritical fluid extract from chestnut shells upon intestinal permeability, Food Research International, 2024, 175, 113807
https://doi.org/10.1016/j.foodres.2023.113807

4. Diana Pinto, Andreia Almeida, Vitor Freitas, Anna Queralt, Cristina Delerue-Matos, Bruno Sarmento, Francisca Rodrigues, Appraisal of a new potential antioxidants-rich nutraceutical ingredient from chestnut shells through in-vivo assays – A targeted metabolomic approach in phenolic compounds, Food Chemistry, 2023, 404, 134546
https://doi.org/10.1016/j.foodchem.2022.134546

5. Diana Pinto, Anallely López-Yerenab, Rosa Lamuela-Raventósb, Anna Vallverdú-Queraltb, Cristina Delerue-Matos, Francisca Rodrigues, Predicting the effects of in-vitro digestion in the bioactivity and bioaccessibility of antioxidant compounds extracted from chestnut shells by supercritical fluid extraction – A metabolomic approach, Food Chemistry, 2024, 435, 137581
https://doi.org/10.1016/j.foodchem.2023.137581

6. Diana Pinto, Ana Sofia Ferreira, Julián Lozano-Castellón, Emily P. Laveriano-Santos, Rosa M. Lamuela-Raventós, Anna Vallverdú-Queralt, Cristina Delerue-Matos, Francisca Rodrigues, Exploring the impact of in-vitro gastrointestinal digestion in the bioaccessibility of phenolics-rich chestnut shells – A preliminary study, Separations, 2023, 10(9), 471
https://doi.org/10.3390/separations10090471

7. Diana Pinto, Ana Margarida Silva, Stefano Dall’Acqua, Stefania Sut, Anna Vallverdú-Queralt, Cristina Delerue-Matos, Francisca Rodrigues, Simulated gastrointestinal digestion of chestnut (Castanea sativa Mill.) shells extract prepared by Subcritical Water Extraction: Bioaccessibility, bioactivity and intestinal permeability by in-vitro assays, Antioxidants, 2023, 12(7), 1414
https://doi.org/10.3390/antiox12071414

8. Diana Pinto, Manuela M. Moreira, Jaroslava Švarc-Gajić, Anna Vallverdú-Queralt, Tanja Brezo-Borjan, Cristina Delerue-Matos, Francisca Rodrigues, In-vitro gastrointestinal digestion of functional cookies enriched with chestnut shells extract: Effects on phenolic composition, bioaccessibility, bioactivity, and α-amylase inhibition, Food Bioscience, 2023, 53, 102766
https://doi.org/10.1016/j.fbio.2023.102766

9. Diana Pinto, Anallely López-Yerena, Andreia Almeida, Bruno Sarmento, Rosa Lamuela-Raventós, Anna Vallverdú-Queralt, Cristina Delerue-Matos, Francisca Rodrigues, Metabolomic insights into phenolics-rich chestnut shells extract as a nutraceutical ingredient – A comprehensive evaluation of its impacts on oxidative stress biomarkers by an in-vivo study, Food Research International, 2023, 170, 112963
https://doi.org/10.1016/j.foodres.2023.112963

10. Diana Pinto, Manuela M. Moreira, Elsa F. Vieira, Jaroslava Švarc-Gajić, Anna Vallverdú-Queralt, Tanja Brezo-Borjan, Cristina Delerue-Matos, Francisca Rodrigues, Development and characterization of functional cookies enriched with chestnut shells extract as source of bioactive phenolic compounds, Foods, 2023, 12, 640.
https://doi.org/10.3390/foods12030640

11. Diana Pinto, Andreia Almeida, Anallely López-Yerena, Soraia Pinto, Bruno Sarmento, Rosa Lamuela-Raventós, Anna Vallverdú-Queralt, Cristina Delerue-Matos, Francisca Rodrigues, Appraisal of a new potential antioxidants-rich nutraceutical ingredient from chestnut shells through in-vivo assays – A targeted metabolomic approach in phenolic compounds, Food Chemistry, 2023, 404, 134546
https://doi.org/10.1016/j.foodchem.2022.134546

12. Ana Sofia Ferreira, Ana Margarida Silva, Diana Pinto, Manuela M. Moreira, Ricardo Ferraz, Jaroslava Švarc-Gajíc, Paulo C. Costa, Cristina Delerue-Matos, Francisca Rodrigues, New Perspectives on the Sustainable Employment of Chestnut Shells as Active Ingredient against Oral Mucositis: A First Screening, International Journal of Molecular Sciences, 2022, 23, 14956
https://doi.org/10.3390/ijms232314956

13. Nágilla Oliveira, Maria de la Luz Cádiz-Gurrea, Ana Margarida Silva, Catarina Macedo, Francisca Rodrigues, Paulo Costa, Development and Optimization of a Topical Formulation with Castanea sativa Shells Extract Based on the Concept “Quality by Design”, Sustainability, 2022, 14, 129.
https://www.mdpi.com/2071-1050/14/1/129

14. Diana Pinto, María de la Luz Cádiz-Gurrea, Juliana Garcia, Maria José Saavedra, Vitor Freitas, Paulo Costa, Bruno Sarmento, Cristina Delerue-Matos, Francisca Rodrigues, From soil to cosmetic industry: Validation of a new cosmetic ingredient extracted from chestnut shell through environmentally friendly techniques, Sustainable Materials & Technologies 2021, 29, e00309
https://www.sciencedirect.com/science/article/pii/S2214993721000646

15. Diana Pinto, Fátima Lameirão, Cristina Delerue-Matos, Francisca Rodrigues, Paulo Costa, Characterization and Stability of a Formulation Containing Antioxidants-Enriched Castanea sativa Shells Extract. Cosmetics, 2021, 8, 49
https://www.mdpi.com/2079-9284/8/2/49

16. Diana Pinto, Maria de la Luz Cádiz-Gurrea, Anna Queralt, Cristina Delerue-Matos, Francisca Rodrigues, Castanea sativa shells: A review on phytochemical composition, bioactivity and waste management approaches for industrial valorization, Food Research International, 2021, 144, 110364.
https://www.sciencedirect.com/science/article/pii/S0963996921002635

17. Diana Pinto, Ana M. Silva, Vitor Freitas, Anna Vallverdú-Queralt, Cristina Delerue-Matos, Francisca Rodrigues, Microwave-Assisted Extraction as a Green Technology Approach to Recover Polyphenols from Castanea sativa Shells, ACS Food Science & Technology, 2021, 1, 2, 229–241.
https://pubs.acs.org/doi/10.1021/acsfoodscitech.0c00055

18. Diana Pinto, Elsa Vieira, Andreia F. Peixoto, Cristina Freire, Vitor Freitas, Paulo Costa, Cristina Delerue-Matos, Francisca Rodrigues, Optimizing the extraction of phenolic antioxidants from chestnut shells by subcritical water extraction using response surface methodology, Food Chemistry, Food Chemistry, 2021, 334, 127521.
https://www.sciencedirect.com/science/article/pii/S0308814620313832

19. Diana Pinto, María de la Luz Cádiz-Gurrea, Stefania Sut, Ana Sofia Ferreira, Francisco Javier Leyva-Jimenez, Stefano Dall’Acqua, Antonio Segura-Carretero, Cristina Delerue-Matos, Francisca Rodrigues, Valorisation of underexploited Castanea sativa shells bioactive compounds recovered by Supercritical Fluid Extraction with CO2: A Response Surface Methodology approach, Journal of CO2 Utilization, 40, 101194, 2020.
https://www.sciencedirect.com/science/article/pii/S2212982020301529

20. Fátima Lameirão, Diana Pinto, Elsa F. Vieira, Andreia F. Peixoto, Cristina Freire, Stefania Sut, Stefano Dall’Acqua, Paulo Costa, Cristina Delerue-Matos, Francisca Rodrigues, Green-sustainable recovery of phenolic and antioxidant compounds from industrial chestnut shells using ultrasound-assisted extraction: Optimization and evaluation of biological activities in vitro, Antioxidants, 9, 267, 2020.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139998/

21. Diana Pinto, Cristina Delerue-Matos, Francisca Rodrigues, Bioactivity, phytochemical profile and pro-healthy properties of Actinidia arguta: A review, Food Research International, 136, 109449, 2020.
https://www.sciencedirect.com/science/article/pii/S0963996920304749

22. Olena Dorosh, Manuela M. Moreira, Diana Pinto, Andreia F. Peixoto,
Cristina Freire, Paulo Costa, Francisca Rodrigues, Cristina Delerue-Matos, Evaluation of the extraction temperature influence on polyphenolic
profiles of vine-canes (Vitis vinifera) subcritical water extracts, Foods, 9(7), 872, 2020
https://www.mdpi.com/2304-8158/9/7/872

23. Manuela M. Moreira, Francisca Rodrigues, Olena Dorosh, Diana Pinto, Paulo C. Costa, Jaroslava Švarc-Gajic, Cristina Delerue-Matos, Vine-canes as a source of value-added compounds for cosmetic formulations, Molecules, 25(13), 2969, 2020.
https://www.mdpi.com/1420-3049/25/13/2969

Book Chapters

1. Diana Pinto, María de la Luz Cádiz Gurrea, Ana Margarida Oliveira, Cristina Delerue-Matos, Francisca Rodrigues, Food Wastes, “Cosmetics” (Ed. Charis M. Galanakis), Woodhead Publishing, 503-528, 2021. URL: https://www.sciencedirect.com/science/article/pii/B9780128205631000044

2. Diana Pinto, Nair Braga, Ana Margarida Silva, Cristina Delerue-Matos, Francisca Rodrigues, Chestnut, Valorization of fruit processing by-products, “Chestnut” (Ed. Charis M. Galanakis), Woodhead Publishing, 127-144, 2019. URL: https://www.sciencedirect.com/science/article/pii/B978012817106600006X

3. Maria de la Luz Cádiz Gurrea, Sónia Soares, Francisco Jiménez, Álvaro F. Ochoa, Diana Pinto, Cristina Delerue-Matos, António Segura Carretero, Francisca Rodrigues, Effects of nutritional supplements on human health, “Nutraceuticals & Natural Product Pharmaceuticals”, edited by Charis M. Galanakis, Woodhead Publishing, 105-140, 2019. URL: https://www.sciencedirect.com/science/article/pii/B9780128164501000040

Ongoing PhD Thesis

1. Ana Sofia Ferreira, Eco-innovative strategy to valorise chestnut (Castanea sativa) shells as active ingredient for oral films: A New approach to prevent/threat oral mucositis, PhD in Sustainable Chemistry, Faculty of Sciences, University of Porto, on going (Grant: Fundação para a Ciêcnia e a Tecnologia (FCT) (Portugal) – 2020.07519.BD)

2. Diana Pinto, Castanea sativa shells: An industrial by-product as source of active ingredients for functional foods, PhD in Sustainable Chemistry, Faculty of Sciences, University of Porto, on going Grant: Fundação para a Ciêcnia e a Tecnologia (FCT) (Portugal) – SFRH/BD/144534/2019)

Master Thesis Concluded

1. Leonardo José Oliveira Amaral, Development of biodegradable polymer films from Castanea sativa shells polysaccharides, Master in Chemical Engineering, Superior Institute of Engineering of Porto, October 2020
https://recipp.ipp.pt/bitstream/10400.22/16430/1/DM_LeonardoAmaral_2020_MEQ.pdf

2. Manuel Hidelbrando de Souza Júnior, Aspetos Regulamentares de Nanomateriais em Cosméticos, Master in Pharmaceutical Technology, Faculty of Pharmacy, University of Porto, November 2020
https://sigarra.up.pt/ffup/pt/noticias_geral.ver_noticia?p_nr=31737

3. Nágilla Silva de Oliveira, Desenvolvimento e otimização de uma formulação tópica com extrato de cascas de Castanea sativa baseado no conceito “Quality by design”, Master in Pharmaceutical Technology, Faculty of Pharmacy, University of Porto, November 2020
https://repositorio-aberto.up.pt/handle/10216/131631

4. Diana Pinto, Response surface evaluation of Subcritical Water Extraction conditions of Castanea sativa shells bioactive compounds: A cosmetic application, Master in Quality Control, Faculty of Pharmacy, University of Porto, October 2019 https://repositorio-aberto.up.pt/handle/10216/124466

5. M.ª de Fátima Lamarão, Extração de cascas de Castanea sativa por Técnica Assistida de Ultrassons: Caracterização química e aplicação cosmética, Master in Quality Control, Faculty of Pharmacy, University of Porto, October 2019
https://repositorio-aberto.up.pt/handle/10216/124452

6. Sabrina Padoin Tassotti, Desenvolvimento e caracterização de um creme hidrófilo com extrato de cascas de Castanea sativa, Master in Pharmaceutical Technology, Faculty of Pharmacy, University of Porto, October 2019
https://repositorio-aberto.up.pt/handle/10216/124395

Oral Presentations in International Conferences

1. Francisca Rodrigues, Chestnut shells as new potential active ingredient: An exploratory approach employing eco-friendly techniques, 1st Novel Food Webinar: based on new ingredients, materials and processes, January 2022, virtual conference
https://systemic-hub.eu/events/

2. Diana Pinto, María de la Luz Cádiz-Gurrea, Victor Freitas, Paulo Costa, Bruno Sarmento, Cristina Delerue-Matos, Francisca Rodrigues, Chestnut shells eco-friendly extracts as promising anti-aging ingredients for greener cosmetic formulations, 12th International Conference on Skin Ageing & Challenges, November 2021, virtual conference
https://skin-challenges.com/wp-content/uploads/dlm_uploads/2021/07/Skin-2021-Agenda-V23-26-10.pdf

3. Diana Pinto, María de la Luz Cádiz-Gurrea, Victor Freitas, Paulo Costa, Bruno Sarmento, Cristina Delerue-Matos, Francisca Rodrigues, From soil to cosmetic industry: Validation by in-vitro, Controlled Release Society 2021 – Virtual Annual Meeting, July 2021, virtual conference.
https://2021.controlledreleasesociety.org/delivery-technologies-in-cosmetics-and-consumer-products–cdp-i.html

4. Francisca Rodrigues, Valorization of food byproducts as new sources of bioactive compounds, Course of “Pharmacotechnics: Research, Development and Innovation”, September 2020, University of Maringá, virtual event

5. Francisca Rodrigues, Valorization of food by-products for cosmetic purposes, 12th International Congress of Pharmaceutical Sciences (CIFARP), November 2019, Ribeirão Preto, Brazil
https://2019.cifarp.com.br/program-2/

6. Francisca Rodrigues, Crop waste as sources of bioactive compounds, International Summer School – Biodiversity, Bioprospecting and territories: future challenges in the area of conservation, management and health, September 2019, Padova, Italy
https://www.dsfarm.unipd.it/biodiversity-bioprospecting-and-territories-0

Posters in International Conferences

1. Diana Pinto, Maria de la Luz Cádiz-Gurrea, Vitor Freitas, Paulo Costa, Bruno Sarmento, Cristina Delerue-Matos, Francisca Rodrigues, Castanea sativa shells: Is cosmetic industry a prominent opportunity to valorise this agro-waste?, The 2nd Electronic Conference on Future Foods and Food Technologies for a Sustainable World, October 2021, virtual conference
https://foods2021.sciforum.net/

2. Diana Pinto, María de la Luz Cádiz-Gurrea, Vitor Freitas, Paulo Costa, Bruno Sarmento, Cristina Delerue-Matos, Francisca Rodrigues, Study of a possible cosmetic ingredient recovered from Castanea sativa shells using a green technology approach through in-vitro and ex-vivo assays, Controlled Release Society 2021 – Virtual Annual Meeting, July 2021, virtual conference.
https://2021.controlledreleasesociety.org/delivery-technologies-in-cosmetics-and-consumer-products–cdp-i.html

3. Diana Pinto, Elsa F. Vieira, Andreia F. Peixoto, Vitor Freitas, Paulo Costa, Cristina Delerue-Matos, Francisca Rodrigues, Chestnut (Castanea sativa Mill.) shells: A promising source of polyphenols as valuable compounds for cosmetic industry, XXX International Congress on Polyphenols, July 2021, virtual conference.
https://icp2020turku.utu.fi/wp-content/uploads/2021/07/The-schedule-for-the-ICP2020TURKU-080721.pdf

4. Diana Pinto, Ana Margarida Silva, Cristina Delerue-Matos, Francisca Rodrigues, Application of a green extraction technique to the sustainable recovery of polyphenols from Castanea sativa shells: Bioactivity, in vitro radical scavenging ability and effects on intestinal cells, Iberophenol International Congress, November 2020, virtual conference
https://www.uc.pt/ffuc/ficheiros/Flyer_Iberphenol_International_Conference_2020.pdf

5. Diana Pinto, Elsa F. Vieira, Andreia F. Peixoto, Stefania Sut, Stefano Dall’Acqua, Bruno Sarmento, Paulo Costa, Cristina Delerue-Matos, Francisca Rodrigues, Optimization of Ultrasound-Assisted Extraction of phenolic and antioxidant compounds from industrial chestnut shells using response surface methodology: A new potential cosmetic ingredient, 47th Controlled Release Society (CRS), June 2020, virtual conference
https://www.controlledreleasesociety.org/events/2020-crs-virtual-annual-meeting

6. Diana Pinto, María de la Luz Cádiz-Gurrea, Francisco Javier Leyva-Jimenez, Stefania Sut, Stefano Dall’Acqua, Antonio Segura-Carretero, Cristina Delerue-Matos, Francisca Rodrigues, Valorisation of undervalued chestnut (Castanea sativa Mill.) shell bioactive compounds recovered by Supercritical Fluid Extraction: A promising nutraceutical ingredient, 47th Controlled Release Society (CRS), June 2020, virtual conference
https://2020.controlledreleasesociety.org/

7. Maria de La Luz Gurrea Cadiz, Diana Pinto, Antonio Segura-Carretero, Cristina Delerue-Matos, Francisca Rodrigues, Enriched extract from olive industry by-products as functional ingredients for high value-added products, 47th Controlled Release Society (CRS), June 2020, virtual conference
https://2020.controlledreleasesociety.org/

8. Diana Pinto, Andreia F. Peixoto, Cristina Freire, Cristina Delerue-Matos, Francisca Rodrigues, Bioactivity and radical scavenging capacity of Castanea sativa shell extract obtained by subcritical water extraction, 4th Meeting of Medicinal Biotechnology, Porto, Maio 2019.
http://paginas.ess.ipp.pt/ebtm/programme.html

Oral Presentations in National Conferences

1. Diana Pinto, Elsa F. Vieira, Andreia F. Peixoto, Cristina Freire, Vitor Freitas, Paulo C. Costa, Bruno Sarmento, Cristina Delerue-Matos, Francisca Rodrigues, Valorization of a polyphenols-enriched chestnut shells extract obtained by Subcritical Water Extraction as a novel cosmetic ingredient through ex vivo and in vivo studies, XV Encontro Nacional de Química dos Alimentos, September 2021, virtual conference
http://xveqa.events.chemistry.pt/images/Program_XV_EQA_2021.pdf

2. Diana Pinto, Maria de la Luz Cádiz-Gurrea, Stefania Sut, Francisco Javier Leyva-Jimenez, Stefano Dall’Acqua, Antonio Segura-Carretero. Cristina Delerue-Matos, Francisca Rodrigues, Evaluation of the cosmetic potential of Castanea sativa shells extract prepared by Supercritical Fluids Extraction with CO2 – A preliminary study, 4th Symposium on Chemical and Biological Engineering – Doctoral Congress in Engineering (DCE21), Faculty of Engineering, University of Porto, June 2021, virtual conference.
https://paginas.fe.up.pt/~dce/2021/

3. Diana Pinto, Andreia F. Peixoto, Stefania Sut, Stefano Dall’Acqua, Vitor Freitas, Cristina Delerue-Matos, Francisca Rodrigues, Castanea sativa shells: From an undervalued agro-residue to a valuable raw material for cosmetic industry, 1st Online International “Congress on Natural products application: Health, Cosmetic and Food”, Polytechnic Institute of Bragança (IPB), February 2021, virtual conference.
http://esa.ipb.pt/naturalproducts/

Posters in National Conferences

1. Diana Pinto, Maria de la luz Cádiz-Gurrea, Stefania Sut, Francisco Leyva-Jimenez, Stefano Dall’Acqua, Antonio Segura-Carretero, Vitor Freitas, Bruno Sarmento, Cristina Delerue-Matos, Francisca Rodrigues, Bioactivity, safety and in vitro intestinal permeability of phenolic compounds extracted from Castanea sativa shells by an environmentally friendly technique – An optimizing study using response surface methodology, XV Encontro Nacional de Química dos Alimentos, September 2021, virtual conference
http://xveqa.events.chemistry.pt/?ver=scientific_program

2. Mariana Lamas, Valentina F. Domingues, Ana Margarida Silva, Cristina Delerue-Matos, Francisca Rodrigues, Virgínia Cruz Fernandes, Assessing the Safety of Pesticides in kiwiberry samples by gas chromatography analysis, XV Encontro Nacional de Química dos Alimentos, September 2021, virtual conference
http://xveqa.events.chemistry.pt/?ver=scientific_program

3. Tiago Fernandes, Manuela M. Moreira, Francisca Rodrigues, Sónia Figueiredo, Cristina Delerue-Matos, Removal of pirimicarb pesticide from aqueous solutions by adsorption onto chestnut shells, XXVI Encontro Nacional da Sociedade Portuguesa de Química, July 2019, Porto, Portugal
http://xxvienspq.eventos.chemistry.pt/images/poster.pdf

4. Diana Pinto, Andreia F. Peixoto, Cristina Freire, Cristina Delerue-Matos, Francisca Rodrigues, Bioactivity and radical scavenging capacity of Castanea sativa shell extract obtained by subcritical water extraction, 4th Meeting of Medicinal Biotechnology, May 2019, Porto, Portugal
http://paginas.ess.ipp.pt/ebtm/BookofAbstracts.pdf

Seminars Organization

1. 1st Online Scientific Morning – Circular economy: Science and industry perspectives, Superior Institute of Engineering of Porto, 4th October 2021

News

1. Francisca Rodrigues, Grupo de Reação e Análises Químicas, Perspetiva Atual – Jornal Sol, Edição 4, Páginas 6 – 10, Novembro 2020.
http://perspetivaatual.pt/wp-content/uploads/2021/01/PA_4-1.pdf