Project:

Kiwi4Health

Start date: 17/01/2022
End date: 16/01/2024
Project reference number: EXPL/BAA-AGR/0663/2021

Exploring the Eco-Innovative Re-Use of Kiwiberry Byproducts as Active Ingredients for Oral Mucositis

Principal Investigator: Francisca Rodrigues
Co Principal Investigator: Paulo Costa

Proposing Institution: REQUIMTE – Rede de Química e Tecnologia

Funding: The project KIWI4HEALTH (EXPL/BAA-AGR/0663/2021; https://doi.org/10.54499/EXPL/BAA-AGR/0663/2021) was funded by the Fundação para a Ciência e a Tecnologia (FCT), Ministério da Ciência, Tecnologia e Ensino Superior, through national funds.

Articles in Peer Reviewed Journals

    1. Filipa Teixeira, Ana Margarida Silva, Berta Estevinho, Stefania Sut, Stefano Dall’Acqua, Cristina Delerue-Matos, Paulo C. Costa, Francisca Rodrigues, Development and characterization of oral mucoadhesive films incorporated with Actinidia argutaextract as active ingredient to prevent/treat oral mucositis, Journal of Drug Delivery and Technology 96 (2024) 105725. https://doi.org/10.1016/j.jddst.2024.105725

    2. Catarina Macedo, Paulo C. Costa, Francisca Rodrigues, Bioactive compounds from Actinidia arguta fruit as a new strategy to fight glioblastoma, Food Research International 175 (2024) 113770. https://doi.org/10.1016/j.foodres.2023.113770

    3. Filipa Teixeira, Ana Margarida Silva, Stefania Sut, Stefano Dall’Acqua, Cristina Delerue-Matos, Berta Estevinho, Paulo C. Costa, Francisca Rodrigues, Development and Characterization of Microparticles with Actinidia arguta Leaves Extract by Spray-Drying: A New Mind-Set Regarding Healthy Compounds for Oral Mucositis, Antioxidants 12 (8) (2023) 1496. https://doi.org/10.3390/antiox12081496

    4. Ana Margarida Silva, Paulo C. Costa, Cristina Delerue-Matos, Francisca Rodrigues, Mathematical development and in vivo safety and efficacy studies of a topical formulation containing Actinidia arguta leaves extract, Journal of Drug Delivery Science and Technology 84 (2023) 104547. https://doi.org/10.1016/j.jddst.2023.104547

    5. Francisca Rodrigues, Fruit by-products as source of new cosmetic ingredients – A case study and future perspectives, Household and Personal Care Today – H&PC today, 18 (1),54-57, 2023. https://www.teknoscienze.com/tks_article/fruit-by-products-as-source-of-new-cosmetic-ingredients-a-case-study-and-future-perspectives/

    6. Catarina Macedo, Ana Margarida Silva, Ana Sofia Ferreira, María de la Luz Cádiz-Gurrea, Álvaro Fernández-Ochoa, Antonio Segura-Carretero, Cristina Delerue-Matos, Paulo Costa, Francisca Rodrigues, Insights into the polyphenols extraction from Actinidia arguta fruit (kiwiberry): A source of pro-healthy compounds, Scientia Horticulturae 313 (2023) 111910. https://doi.org/10.1016/j.scienta.2023.111910

    7. Ana Margarida Silva, Andreia Almeida, Stefano Dall’Acqua, Francesca Loschi, Bruno Sarmento, Paulo C. Costa, Cristina Delerue-Matos, Francisca Rodrigues, Insights into the 3D In Vitro Permeability and In Vivo Antioxidant Protective Effects of Kiwiberry Leaf Extract: A Step Forward to Human Nutraceutical Use, International Journal of Molecular Sciences 23 (22) (2022) 14130. https://doi.org/10.3390/ijms232214130

    8. Ana Margarida Silva, Juliana Garcia, Stefano Dall’Acqua, Paulo Costa, Cristina Delerue-Matos, Francisca Rodrigues, Eco-friendly insights on kiwiberry leaves valorization through in-vitro and in-vivo studies, Industrial Crops and Products 184 (2022) 115090. https://doi.org/10.1016/j.indcrop.2022.115090

    9. Ana Sofia Ferreira, Catarina Macedo, Ana Margarida Silva, Cristina Delerue-Matos, Paulo Costa, Francisca Rodrigues, Natural Products for the Prevention and Treatment of Oral Mucositis – A Review, International Journal of Molecular Sciences 23 (8) (2022) 4385. https://doi.org/10.3390/ijms23084385

    10. Ana Margarida Silva, Diana Pinto, Manuela M. Moreira, Paulo C. Costa, Cristina Delerue-Matos, Francisca Rodrigues, Valorization of Kiwiberry Leaves Recovered by Ultrasound-Assisted Extraction for Skin Application: A Response Surface Methodology Approach, Antioxidants 11 (4) (2022) 763. https://doi.org/10.3390/antiox11040763

    11. Ana Margarida Silva, Ana Sofia Luís, Manuela M. Moreira, Ricardo Ferraz, Tanja Brezo-Borjan, Jaroslava Švarc-Gajic, Paulo C. Costa, Cristina Delerue-Matos, Francisca Rodrigues, Influence of temperature on the subcritical water extraction of Actinidia arguta leaves: A screening of pro-healthy compounds, Sustainable Chemistry and Pharmacy 25 (2022) 100593. https://doi.org/10.1016/j.scp.2021.100593

    Articles in National Journals

    1. Ana Margarida Silva, Paulo C. Costa, Cristina Delerue-Matos, Francisca Rodrigues, Frutos e subprodutos de Actinidia argutacomo fonte de compostos bioativos para diferentes indústrias, Tecnoalimentar, 2023, 36, 2-6. http://www.tecnoalimentar.pt/noticias/frutos-e-subprodutos-de-actinidia-arguta-como-fonte-de-compostos-bioactivos-para-diferentes-indostrias-bibliografia/

    Book Chapters

    1. Ana Margarida Silva, Paulo C. Costa, Cristina Delerue-Matos, Francisca Rodrigues, Frutos e subprodutos de Actinidia argutacomo fonte de compostos bioativos para diferentes indústrias, Tecnoalimentar, 2023, 36, 2-6. http://www.tecnoalimentar.pt/noticias/frutos-e-subprodutos-de-actinidia-arguta-como-fonte-de-compostos-bioactivos-para-diferentes-indostrias-bibliografia/

    Ongoing PhD Thesis

    1. Ana Margarida Silva, From soil to skin: Eco-friendly extract from kiwiberry leaves for prevention of skin aging process, PhD in Sustainable Chemistry, Faculty of Sciences, University of Porto (Grant: Fundação para a Ciêcnia e a Tecnologia (FCT) (Portugal) – SFRH/BD/144994/2019)

    Master Thesis Concluded

    1. Filipa Teixeira, Ultrasound-Assisted Extraction of goji berries: Bioactive composition and pro-healthy properties, Master in Health Biochemistry, Superior School of Health – Polytechnic Institute of Porto, November 2023

    2. Eva Rodas, Encapsulation of Kiwiberry pomace extracts, Master in Development of Drugs and Health Products, University of Paris-Saclay, July 2022

    Other Internship Report

    1. Catarina Macedo, Exploring the Eco-Innovative Re-Use of Kiwiberry, Formação com Investigação em Química Sustentável, Faculdade de Ciências e Tecnologia, Universidade Nova Lisboa, January 2023
    2. Ana Celeste Soares Correia, Encapsulation of Actinidia arguta fruit extracts: A new approach for Oral Mucositis, Research Initiation Scholarships – Verão com Ciência, September 2022

    Oral Presentations in International Conferences

    1. Filipa Teixeira, Ana Margarida Silva, Cristina Delerue-Matos, Paulo C. Costa, Francisca Rodrigues, Incorporation of an Actinidia arguta fruit extract in buccal films for the treatment/prevention of oral mucositis, 6th edition of the ISEKI E-conference – “Food Production Based on Food Safety, Sustainable Development and Circular Economy”, November 2023, virtual conference. https://isekieconf23.meetinghand.net/en/4562-conference-programme

    2. Ana Margarida Silva, Paulo C. Costa, Cristina Delerue-Matos, Francisca Rodrigues, Kiwiberry leaves extract as new eco-friendly cosmetic ingredient: assessment of in-vitro and in-vivo safety and inclusion in a topical formulation development, XXXI International Conference on Polyphenols, July 2023, Nantes, France. https://icp2023.symposium.inrae.fr/scientific-program

    3. Ana Margarida Silva, Andreia Almeida, Stefano Dall’Acqua, Francesca Loschi, Bruno Sarmento, Paulo C. Costa, Cristina Delerue-Matos, Francisca Rodrigues, Assessment of the 3D in-vitro permeability and in-vivo antioxidant effects of the Actinidia arguta leaves, 4th SPLC-CRS Young Scientists Meeting, February 2023, Porto, Portugal. https://www.splc-crs.org/meeting-2023/

    4. Ana Margarida Silva, Stefano Dall’Acqua, Francesca Loschi, Paulo Costa, Cristina Delerue-Matos, Francisca Rodrigues, Valorization of Actinidia argutaleaves extracts: Bioactive compounds, in-vitro antioxidant activity and 3D intestinal permeability, 5th edition of the ISEKI e-conferences – “Current food innovation trends; the texture and consumer perception perspective”, November 2022, virtual conference. https://isekieconf22.meetinghand.net/en/3675-conference-programme

    5. Ana Margarida Silva, Paulo Costa, Cristina Delerue-Matos, Francisca Rodrigues, Assessment of in-vitro and in-vivo safety of the Actinidia argutaleaves as a new sustainable cosmetic ingredient, 5th edition of the ISEKI e-conferences – “Current food innovation trends; the texture and consumer perception perspective”, November 2022, virtual conference. https://isekieconf22.meetinghand.net/en/3675-conference-programme

    6. Ana Margarida Silva, Andreia Almeida, Stefano Dall’Acqua, Bruno Sarmento, Paulo C. Costa, Cristina Delerue-Matos, Francisca Rodrigues, From in-vitro to in-vivo evaluation of a new nutraceutical ingredient obtained from kiwiberry (Actinidia arguta) leaves, 15thInternational Congress of Toxicology, September 2022, Maastricht, Netherlands. https://www.iutox.org/ict.asp

    7. Ana Margarida Silva, Paulo Costa, Cristina Delerue-Matos, Francisca Rodrigues, In vitro and in vivo screening of kiwiberry leaves extract as potential cosmetic ingredient. 4th International Symposium on Lipid Oxidation and Antioxidants, May 2022, Vigo (Spain). https://veranstaltungen.gdch.de/microsite/index.cfm?l=11144&modus=

    Posters in International Conferences

    1. Ana Margarida Silva, Andreia Almeida, Stefano Dall’Acqua, Bruno Sarmento, Paulo C. Costa, Cristina Delerue-Matos, Francisca Rodrigues, In-vitro and in-vivo evaluation of kiwiberry (Actinidia arguta) leaves extract as new nutraceutical ingrediente, 8thInternational Conference on FOOD DIGESTION, April 2024, Porto, Portugal. https://www.icfd2024.com/

    2. Catarina Macedo, Ana Margarida Silva, Ana Sofia Ferreira, María de la Luz Cádiz-Gurrea, Álvaro Fernández-Ochoa, Antonio Segura-Carretero, Cristina Delerue-Matos, Paulo Costa, Francisca Rodrigues, From Discarded to Desirable: Actinidia arguta (Kiwiberry) as a Source of Health-Promoting Compounds, 6th edition of the ISEKI E-conference – “Food Production Based on Food Safety, Sustainable Development and Circular Economy”, November 2023, virtual conference. https://isekieconf23.meetinghand.net/en/4562-conference-programme

    3. Ana Margarida Silva, Andreia Almeida, Stefano Dall’Acqua, Bruno Sarmento, Paulo C. Costa, Cristina Delerue-Matos, Francisca Rodrigues, Kiwiberry (Actinidia arguta) leaves as sustainable nutraceutical ingredient: in vitro and in vivo studies, Controlled Release Society 2023, July 2023, Las Vegas, United States of America. https://www.eventscribe.net/2023/CRSAnnualMeeting/

    4. Ana Margarida Silva, Juliana Garcia, Paulo Costa, Cristina Delerue-Matos, Francisca Rodrigues, Highlighting the bioactivity of kiwiberry leaves extracts as cosmetic ingredient – An exploratory in vitro study, 2º Encuentro Ibérico de Fluidos Supercríticos, March 2022, Coimbra (Portugal). https://flucomp.es/eventos/eifs2022

    5. Catarina Macedo, Ana Margarida Silva, Paulo Costa, Cristina Delerue-Matos, Francisca Rodrigues, Valorization of Kiwiberry Leaves by Subcritical Water Extraction: Screening of Antioxidant/Antiradical Activity and Intestinal Effects. 4th International Symposium on Lipid Oxidation and Antioxidants, May 2022, Vigo (Spain). https://veranstaltungen.gdch.de/microsite/index.cfm?l=11144&modus=

    6. Ana Margarida Silva, Andreia Almeida, Stefano Dall’Acqua, Bruno Sarmento, Paulo C. Costa, Cristina Delerue-Matos, Francisca Rodrigues, From in-vitro to in-vivo evaluation of a new nutraceutical ingredient obtained from kiwiberry (Actinidia arguta) leaves, 15thInternational Congress of Toxicology, September 2022, Maastricht (The Netherlands). https://www.iutox.org/ict.asp

    7. Ana Margarida Silva, Andreia Almeida, Bruno Sarmento, Paulo C. Costa, Cristina Delerue-Matos, Francisca Rodrigues, Insights into the development of Actinidia arguta leaves nutraceutical ingredient: Antioxidant activity and bioavailability study in rats, 5º Encontro em Biotecnologia Medicinal/ 2nd Iberian Congress on Medicinal Biotechnology, October 2022, Porto (Portugal). https://www.ess.ipp.pt/noticias/medicinal-biotechnology-5th-meeting-and-2nd-iberian-congress

    Oral Presentations in National Conferences

    1. Filipa Teixeira, Ana Margarida Silva, Cristina Delerue-Matos, Paulo C. Costa, Francisca Rodrigues, Potential of Actinidia argutafruit extract incorporated in buccal films as active ingredient to treat/prevent oral mucositis symptoms, PhD Day 2023 (5ª Edição) – The impact of Science: How research shapes society?, October 2023, Paredes, Portugal. https://phday2023cespu.wixsite.com/phd-day2023

    2. Ana Margarida Silva, Paulo C. Costa, Cristina Delerue-Matos, Francisca Rodrigues, Sustainable application of Actinidia argutaleaves as active ingredient in topical formulation: Development, optimization and in vivo evaluation, 5th Doctoral Congress in Engineering, June 2023, Porto, Portugal. https://fe.up.pt/dce/2023/

    3. Filipa Teixeira, Ana Margarida Silva, Cristina Delerue-Matos, Berta Estevinho, Paulo C. Costa, Francisca Rodrigues, Microparticles containing Actinidia arguta extracts prepared by spray drying, 8th Portuguese Young Chemists Meeting (PYCheM), May 2023, Vila Real, Portugal. https://8pychem.events.chemistry.pt/list-of-communications

    4. Ana Margarida Silva, Paulo Costa, Cristina Delerue-Matos, Francisca Rodrigues, Avaliação in-vitro e in-vivo de extrato de folhas de baby kiwi (Actinidia arguta): Um novo ingrediente cosmético?, 2ª Edição Sunset Skin Summit, October 2022, virtual conference. https://www.ff.ulisboa.pt/eventos/sunset-skin-summit-2a-edicao/

    Posters in National Conferences

    1. Ana Margarida Silva, Andreia Almeida, Stefano Dall’Acqua, Francesca Loschi, Bruno Sarmento, Paulo C. Costa, Cristina Delerue-Matos, Francisca Rodrigues, In vitro and in vivo antioxidant properties of Actinidia arguta leaves obtained by Ultrasound assisted extraction, International Meeting Molecules 4 Life, September 2023, Vila Real, Portugal. https://molecules4life-2023.events.chemistry.pt/

    2. Ana Margarida Silva, Andreia Almeida, Stefano Dall’Acqua, Francesca Loschi, Bruno Sarmento, Paulo C. Costa, Cristina Delerue-Matos, Francisca Rodrigues, Actinidia arguta leaves as potential nutraceutical ingredient: An in vitro and in vivo screening, Dare2Change – Innovation-Driven Agrifood Business, March 2023, Porto (Portugal). https://dare2change.pt/

    Seminars Organization

    1. Webinar “Kiwi4Health – Exploring the Eco-Innovative Re-Use of Kiwiberry Byproducts as Active Ingredients for Oral Mucositis”, 11th January 2024. https://www.graq.isep.ipp.pt/index.php?mact=News,cntnt01,detail,0&cntnt01articleid=75&cntnt01returnid=192

    News

    1. Francisca Rodrigues, “News Kiwi berry leaves extract reveals “excellent cosmetic ingredient” for skin and eye applications, study shows”, June 2022, Available at: https://www.personalcareinsights.com/news/kiwi-berry-leaves-extract-reveals-excellent-cosmetic-ingredient-for-skin-and-eye-applications-study-shows.html

    Awards

    1. Best oral presentation, Filipa Teixeira, Ana Margarida Silva, Cristina Delerue-Matos, Paulo C. Costa, Francisca Rodrigues, Potential of Actinidia arguta fruit extract incorporated in buccal films as active ingredient to treat/prevent oral mucositis symptoms, PhD Day 2023 (5ª Edição) – The impact of Science: How research shapes society?, October 2023, Paredes, Portugal. https://phday2023cespu.wixsite.com/phd-day2023

    2. Best poster communication, Ana Margarida Silva, Andreia Almeida, Stefano Dall’Acqua, Francesca Loschi, Bruno Sarmento, Paulo C. Costa, Cristina Delerue-Matos, Francisca Rodrigues, Actinidia arguta leaves potential nutraceutical ingredient: An in vitro and in vivo screening, Dare2Change – Innovation-Driven Agrifood Business, March 2023, Porto, Portugal. https://dare2change.pt/

    3. 2nd prize for the best oral communication, Ana Margarida Silva, Stefano Dall’Acqua, Francesca Loschi, Paulo Costa, Cristina Delerue-Matos, Francisca Rodrigues, Valorization of Actinidia arguta leaves extracts: Bioactive compounds, in-vitro antioxidant activity and 3D intestinal permeability, 5th edition of the ISEKI e-conferences – “Current food innovation trends; the texture and consumer perception perspective”, November 2022, virtual conference. https://isekieconf22.meetinghand.net/en/3675-conference-programme